首页资讯孕期空气污染物暴露与巨大儿以及儿童期超重肥胖发生风险的前瞻性队列（英文）

孕期空气污染物暴露与巨大儿以及儿童期超重肥胖发生风险的前瞻性队列（英文）

来源：泰然健康网时间：2024年11月22日 10:13

孕期空气污染物暴露与巨大儿以及儿童期超重肥胖发生风险的前瞻性队列（英文）

【摘要】：Background:Decreased semen quality has been associated with ambient fine particulate matter(PM_(2.5)),but its associations with PM_(2.5) constituents are still unknown.Objectives:To quantitatively investigate exposure-response relationships between PM_(2.5) constituents and semen quality.Methods:We studied 1081 men whose partners underwent assisted reproductive technology procedures in a large reproductive medical center in Wuhan,China,and examined their semen quality at least once between 2013 and 2015.Daily PM_(2.5) constituents(metals and water-soluble ions) were continuously determined at two monitoring stations for one week each month.Linear mixed models were used to examine the associations of exposures to PM_(2.5) and its constituents during 90 days before semen examination with semen quality.Results:In consistent with our previous study,PM_(2.5) exposure was significantly associated with decline in sperm concentration(β:-0.12;95%CI:-0.21,-0.03) and sperm count(P:-0.10;95%CI:-0.19,-0.01).We also observed significant associations of PM_(2.5) constituents including Cd,Pb,Mn and Ni with decreased sperm concentration and sperm count(all P for linear trend <0.05).In addition,both Pb and Mn exposures were inversely associated with sperm motility(all P for linear trend <0.05).Sensitivity analyses showed that these associations were relatively robust across different models.Conclusions:Our findings suggest that PM_(2.5) and its constituents(Cd,Pb,Mn and Ni)adversely affect semen quality,especially sperm concentration and count,and add further evidence to reduce ambient PM_(2.5) exposure for men trying to conceive.

1290318664393818112

1 Correlation between sperm DNA 8-Hydroxy-2'-deoxyguanosine level and semen quality[J];Asian Journal of Andrology;2001年04期 2 The Canonical Correlation Analysis on Semen Quality and Serum Heavy Metals in Chinese Young Men[J];Reproduction & Contraception;2003年02期 3 Hu Shan;Zhang Xiao-gang;Han Cong;Wei Shuai-yi;Xie Dong-qi;Du Ren-rang;Hu Jian-hong;Effects of Three Different Diluents on Quality of Boar Semen Stored at 17℃[J];Journal of Northeast Agricultural University(English Edition);2015年02期 4 M.E.Hammadeh,P.M.Zavos,P.Rosenbaum,W.SchmidtComparison between the quality and function of sperm after semen processing with two different methods[J];Asian Journal of Andrology;2001年02期 5 Principal Component Analysis on Semen Quality among Chinese Young Men[J];Reproduction & Contraception;2003年01期 6 Impact of Organophosphorous Pesticide Exposure on Semen Quality[J];Reproduction & Contraception;2003年03期 7 Casey L.Durfey;Sabrina E.Swistek;Shengfa F.Liao;Mark A.Crenshaw;Henry J.Clemente;Rooban V.K.G.Thirumalai;Christy S.Steadman;Peter L.Ryan;Scott T.Willard;Jean M.Feugang;Nanotechnology-based approach for safer enrichment of semen with best spermatozoa[J];Journal of Animal Science and Biotechnology;2019年02期 8 石其贤,钟翠玲,叶蓁,刘良初SPERMINE——AN INHIBITION OF in vitro CAPACITATION AND FERTILIZATION IN HAMSTER SPERM[J];Chinese Science Bulletin;1989年21期 9 Does exposure to computers affect the routine parameters of semen quality?[J];Asian Journal of Andrology;2005年03期 10 江鱼,王益鑫,李世勤,陈振兴,任鸿娣,韩银法,钱宪民,陈伟,廖志康SEMEN ANALYSIS OF 542 CHINESE MEN WITH NORMAL FERTILITY[J];Journal of Shanghai Second Medical University;1987年02期

孕期空气污染物暴露与巨大儿以及儿童期超重肥胖发生风险的前瞻性队列（英文）