茶多酚对肠道微生物的调节作用研究进展

摘要： 代谢综合征是高血压、血糖异常、血脂紊乱和肥胖症等疾病在人体内集结的一组复杂的代谢紊乱症候群。茶多酚是茶叶中的特征次生代谢产物之一,最新研究表明,茶多酚可以通过对肠道菌群的干预,改善肠道菌群紊乱,调节宿主-肠道菌群的共代谢过程,进而达到改善代谢综合征的目的。本文系统总结了茶多酚的吸收与代谢,以及茶多酚在体外发酵模型、动物试验和临床试验中对肠道菌群的影响,阐述了茶多酚-微生物群-宿主三者之间的内在作用机制,有助于以肠道菌群理论为基础探讨茶多酚对人体健康的作用,并为茶多酚的功能性产品开发提供理论依据。

关键词: 茶多酚, 吸收与代谢, 肠道菌群, 代谢综合征

Abstract: Metabolic syndrome (MS) is an abnormal multi-metabolic disease that comprises a combination of various diseases such as hypertension, abnormal blood sugar, dyslipidemia and obesity. Tea polyphenols (TPs) are the characteristics secondary metabolites in tea leaves. The latest studies show that TPs can improve the disorder of gut flora (GF) and modulate the co-metabolism of Host-GF by the intervention & treatment to achieve the goal of improving MS. This paper systematically summarized the absorption and metabolism of TPs and the effects of TPs on GF in in vitro fermentation models, animal experiments, and clinical trials. The underlying mechanism among TPs-GF-Host was described, which would facilitate further exploring the effects of TPs on human health based on the theory of intestinal flora and developing functional products of TPs. In addition, it also provided theoretical foundation for developing functional products associating with TPs.

Key words: tea polyphenols, absorption and metabolism, gut flora, metabolic syndrome

中图分类号: 

S571.1

Q946.84+1

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