首页资讯健康的生活方式可降低有妊娠高血压遗传倾向妇女的心血管风险

健康的生活方式可降低有妊娠高血压遗传倾向妇女的心血管风险

来源：泰然健康网时间：2025年05月24日 05:08

健康的生活方式可降低有妊娠高血压遗传倾向妇女的心血管风险

Sang‑Hyuk Jung, Haemin Kim, Young Mi Jung, Manu Shivakumar, Brenda Xiao, Jaeyoung Kim, Beomjin Jang, Jae-Seung Yun, Hong-Hee Won, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Seung Mi Lee

摘要

妊娠期高血压疾病的遗传风险与动脉粥样硬化性心血管疾病的发展有关。然而，生活方式和代谢综合征对动脉粥样硬化性心血管疾病的影响尚未得到评估。在这里，我们评估了这些因素与有妊娠期高血压疾病遗传风险的女性动脉粥样硬化性心血管疾病之间的长期关联。我们使用来自大规模GWAS的全基因组多基因风险评分来评估妊娠期高血压疾病的遗传风险。动脉粥样硬化性心血管疾病的发生率根据遗传风险、生活方式和代谢综合征来评估。妊娠期高血压疾病遗传风险高的个体发生动脉粥样硬化性心血管疾病的几率比遗传风险低的个体高53.0%。然而，在高遗传风险组（前20%）中，通过维持理想的代谢综合征状态和健康的生活方式，发生动脉粥样硬化性心血管疾病的风险降低了64.6%，在低遗传风险组（后20%）中，这一风险降低了65.4%。这些发现强调，保持健康的生活方式对降低动脉粥样硬化性心血管疾病的风险同样有效，而不依赖于妊娠期高血压疾病的遗传风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

摘要图片

Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy

The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy. We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. The incidence of atherosclerotic cardiovascular disease is evaluated according to genetic risk, lifestyle, and metabolic syndrome. Individuals with a very high genetic risk for hypertensive disorders of pregnancy have a 53.0% higher chance of developing atherosclerotic cardiovascular disease than those with a low genetic risk. However, the risk of developing atherosclerotic cardiovascular disease is reduced by up to 64.6% through the maintenance of an ideal metabolic syndrome status and a healthy lifestyle in the high genetic risk group (top 20%), and by up to 65.4% in the low genetic risk group (bottom 20%). These findings emphasize that maintaining a healthy lifestyle in women is equally effective at reducing the risk of atherosclerotic cardiovascular disease independent of genetic risk for hypertensive disorders of pregnancy.

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来源期刊

Nature Communications

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.

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