发酵燕麦对健康成年人免疫炎症因子和肠道健康的调节作用

摘要： 目的：探究发酵燕麦对健康成年人免疫和肠道的调节作用，为发酵燕麦在提升免疫力和肠道健康方面的食用推荐提供科学依据。方法：本研究共招募50～65 岁的健康成年人75 例，并随机分为3 组，包括对照组（15 g/d未发酵燕麦）、低剂量组（5 g/d发酵燕麦）和高剂量组（15 g/d发酵燕麦），干预周期为30 d。干预前后采集血液、粪便样本进行免疫炎症因子、肠道菌群的检测，并利用调查问卷记录排便状况。结果：发酵燕麦干预可显著提高健康成年人的排便满意度。发酵燕麦干预可有效降低健康成年人血清中白细胞介素（interleukin，IL）-1β、IL-6和肿瘤坏死因子-α的水平。发酵燕麦干预能够显著增加肠道双歧杆菌（Bifidobacterium）和乳酸杆菌（Lactobacillus）的水平。结论：发酵燕麦能够提升健康成年人的排便体感，调节免疫炎症因子水平，促进肠道有益菌增殖，是具有后生元效应的健康谷物类食品。

关键词: 发酵燕麦, 人群试验, 肠道健康, 免疫调节, 后生元

Abstract: Objective: To investigate the regulatory effect of fermented oat on immunity and gut health in healthy adults in order to provide scientific evidence supporting dietary recommendations to enhance immune function and gut health. Methods: A total of 75 healthy adults aged 50–65 years were recruited and randomly assigned to three groups: a control group (15 g/day of unfermented oat), a low-dose group (5 g/day of fermented oat), and a high-dose group (15 g/day of fermented oat) and the intervention period lasted for 30 days. Blood and fecal samples were collected before and after the intervention to assess immune-inflammatory factors and gut microbiota, and questionnaires were used to record bowel movement conditions. Results: Fermented oat intervention significantly improved bowel movement satisfaction in healthy adults. The intervention effectively reduced the serum levels of interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α). Furthermore, fermented oats significantly increased the levels of Bifidobacterium and Lactobacillus in the gut. Conclusion: Fermented oat can enhance physical sensation of defecation, modulate immune-inflammatory factor levels, and promote the proliferation of beneficial gut bacteria in healthy adults. In summary, fermented oat is a healthy cereal product with postbiotic activity.

Key words: fermented oat, human trial, gut health, immune regulation, postbiotics

中图分类号: 

TS201.4

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