镰状细胞病与妊娠结局：印度古吉拉特邦一个部落地区社区医院的研究

Sickle cell disease (SCD) is a hereditary blood disorder prevalent in tribal regions of India. SCD can increase complications during pregnancy and in turn negatively influence pregnancy outcomes. This study reports the analysis of tribal maternal admissions in the community-based hospital of SEWA Rural (Kasturba Maternity Hospital) in Jhagadia block, Gujarat. The objective of the study is to compare the pregnancy outcomes among SCD, sickle cell trait and non-SCD admissions. This study also estimated the risk of adverse pregnancy outcomes for SCD admissions.

The data pertains to four and half years from March 2011 to September 2015. The total tribal maternal admissions were 14640, out of which 10519 admissions were deliveries. The admissions were classified as sickle cell disease, sickle cell trait and non-sickle cell disease. The selected pregnancy outcomes and maternal complications were abortion, stillbirth, Caesarean section, haemoglobin levels, blood transfusion, preterm pregnancy, newborn birth weight and other diagnosed morbidities (IUGR, PIH, eclampsia, preterm labour pain). The odds ratios for each risk factor were estimated for sickle cell patients. The odds ratios were adjusted for the respective years.

Overall, 1.2% (131 out of 10519) of tribal delivery admissions was sickle cell admissions. Another 15.6% (1645 out of 10519) of tribal delivery admissions have sickle cell trait. The percentage of stillbirth was 9.9% among sickle cell delivery admission compared to 4.2% among non-sickle cell deliveries admissions. Among sickle cell deliveries, 70.2% were low birth weight compared to 43.8% of non-sickle cell patient. Similarly, almost half of the sickle cell deliveries needed the blood transfusion. The 45.0% of sickle cell delivery admissions were pre-term births, compared to 17.3% in non-SCD deliveries. The odds ratio of severe anaemia, stillbirth, blood transfusion, Caesarean section, and low birth weight was significantly higher for sickle cell admissions compared to non-sickle cell admissions.

The study exhibited that there is a high risk of adverse pregnancy outcomes for women with SCD. It may also be associated with the poor maternal and neonatal health in these tribal regions. Thus, the study advocates the need for better management of SCD in tribal Gujarat.

相关知识

妊娠结局环境污染研究
妊娠期感染性疾病研究新进展（临床综述）
妊娠期糖尿病和糖尿病合并妊娠的研究进展
产前多维度健康宣教对门诊妊娠糖尿病病人疾病知识及妊娠结局的影响
妊娠期口腔卫生保健研究进展
妊娠期营养指导及体重管理与妊娠结局的相关性研究
精细化护理模式对妊娠糖尿病患者血糖、心理状态及妊娠结局的影响分析
揭秘印度茶文化的传承与创新：从传统黄金产区到现代玛莎拉茶
妊娠期体重管理研究进展
研究探讨患有镰状细胞病的青少年睡眠健康状况

网址: 镰状细胞病与妊娠结局：印度古吉拉特邦一个部落地区社区医院的研究 https://www.trfsz.com/newsview1901308.html